• Jun Wei, Guo-li Liu, Mei-ying Liang, and Shan-mi Wang.
• Department of Obstetrics, Peking University People's Hospital, Beijing 100044, China.
• Zhonghua Fu Chan Ke Za Zhi. 2009 Sep 1;44(9):665-8.

ObjectiveTo investigate the effect of general anesthesia on pregnancy women with thrombocytopenia and neonate during cesarean section (CS).MethodsSixty-five singleton pregnant women with low platelet count (< 50 x 10(9)/L) and gestation>35 weeks were allocated into general anesthesia group (35 cases) and local anesthesia group (30 cases) randomly. The time from skin incision to fetal delivery, the oxyhemoglobin saturation (SO2) before and after anesthesia, the blood loss during operation, Apgar scores at 1 min, birth weight,umbilical cord blood gas analysis were recorded.ResultsThe mean time from anesthesia induction to fetal delivery was (9.7 +/- 3.5) minutes in general anesthesia group. The time from skin incision to fetal delivery in general anesthesia group [(7.7 +/- 2.5) minutes] was shorter than that in local anesthesia group [(12.5 +/- 3.0) minutes, P < 0.01], while the operation time had no significant differences. There were no significant difference for the value of SO2 before and after general anesthesia or local anesthesia (P > 0.05). There was no significant difference for the blood loss [(471 +/- 245) ml vs. (452 +/- 213) ml, P > 0.05], Apgar scores at 1 minute, birth weight and umbilical cord blood gas analysis between the two groups (P > 0.05). There had two infants with blue asphyxia in local anesthesia group while no infant with asphyxia in general anesthesia group.ConclusionGeneral anesthesia is safe to pregnant women with thrombocytopenia during CS.

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