• A Oppenheim-Eden, L Glantz, L A Eidelman, and C L Sprung.
• Department of Anesthesiology and Critical Care Medicine, Hadassah University Medical Center and The Hebrew University of Jerusalem, Israel. galo@netvision.net.il
• Intensive Care Med. 1999 Jan 1;25(1):63-7.

ObjectiveIntracerebral hemorrhage (ICH) is associated with a high mortality. The present study sought to determine the incidence of spontaneous ICH in an intensive care unit (ICU) and associated factors.DesignA 6 year retrospective study.SettingA general ICU in a university hospital.PatientsAll ICU patients developing ICH were included in the study. All trauma and neurosurgical patients were excluded, as well as patients who were admitted to the ICU because of ICH.Measurements And ResultsDuring the study period 3032 patients were hospitalized in the ICU, and 834 were excluded. The remaining 2198 patients comprised the study population. Computed tomography of the head was performed in a total of 227 patients, and the 9 patients found to have new onset ICH comprise the group of interest. None of these patients were hypertensive. Seven of the patients had either a primary hematologic malignancy or bone marrow transplantation. Eight had thrombocytopenia of <100x10(9)/l (median 10x10(9)/l, range 3-150x10(9)/l), and in 6 it preceded ICH by 5 days or more. Only in one patient were both PTT and PT prolonged. All were mechanically ventilated with high peak inspiratory pressure (PIP) (median 37 cm H2O, range 20-43 cm H2O). Arterial carbon dioxide tension (PaCO2) was considerably elevated (median 65 mm Hg, range 41-87 mm Hg). All of the patients had impaired renal and hepatic function (urea: median 14 mmol/l, range 9.9-52 mmol/l; bilirubin: median 94 micromol/l, range 20-360 micromol/l), and five had septicemia. Eight of the patients bled to other sites before they developed ICH. All patients died shortly after the diagnosis of ICH.ConclusionsSpontaneous nonhypertensive ICH is a rare, fatal event in the ICU. Associated factors include thrombocytopenia, the need for mechanical ventilation, elevated PIP and PaCO2, sepsis, and impaired hepatic and renal function.

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