• Eur. J. Heart Fail. · Dec 2002

    Randomized Controlled Trial Comparative Study Clinical Trial

    Effect of nebivolol on left ventricular function in patients with chronic heart failure: a pilot study.

    • Bernhard R Brehm, Sabine C Wolf, Sandra Görner, Nina Buck-Müller, and Teut Risler.
    • Medizinische Klinik III, Otfried-Müllerstr 10, 72076 Tübingen, Germany. bernhard.brehm@onlinehome.de
    • Eur. J. Heart Fail. 2002 Dec 1;4(6):757-63.

    BackgroundSympathetic activity is a significant predictor of a poor prognosis in heart failure. Beta-blockers have been shown to improve the prognosis of patients with heart failure.AimThis pilot study examined the tolerability and efficacy of the new beta-blocker nebivolol on left ventricular function in patients with chronic heart failure.Methods And ResultsTwelve patients with an ejection fraction of 13-39% were included in this double blind, placebo-controlled randomized trial of nebivolol administered in addition to standard therapy. Exercise time, heart rate, left ventricular function and tolerability were examined at baseline and after 3 months of orally administered nebivolol (2.5 and 5 mg, n = 6) or placebo (n = 6). Nebivolol was well tolerated and the NYHA class improved in four patients. Heart rate decreased while the maximal exercise duration and performance remained stable. Left ventricular function increased (ejection fraction 31.5 +/- 10.11 to 42.0 +/- 10.99%, P < or = 0.01) after 12 weeks of nebivolol. The left ventricular end-systolic diameter decreased in the nebivolol-group from 56.5 +/- 9.40 to 50.2 +/- 9.43 mm (P < or = 0.02).ConclusionThese data indicate that nebivolol might improve cardiac function in patients with reduced left ventricular function.Copyright 2002 European Society of Cardiology

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