• Jung Hye Hwang, Yong Soo Kwon, Eun Hae Kang, Won-Jung Koh, Kyeong Woo Kang, Ho Cheol Kim, Man Pyo Chung, Hojoong Kim, O Jung Kwon, and Gee Young Suh.
• Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
• Korean J. Intern. Med. 2004 Dec 1;19(4):237-42.

BackgroundPartial liquid ventilation (PLV) and prone positioning can improve the arterial oxygenation (PaO2) in acute lung injury (ALI). We evaluated the effect of prolonged prone positioning during partial liquid ventilation (PLV) in a canine model of acute lung injury.MethodsSix mongrel dogs (weighing 17.4 +/- 0.7 kg each) were anesthetized, intubated and mechanically ventilated. After 1 hour of baseline stabilization, the dogs' lungs were instilled with 40 mL/kg perfluorocarbon (PFC). PLV was first performed in the supine position for 1 hour (S1), then in the prone position for 3 hours with hourly measurements (P1, P2, P3), and finally, PLV was performed with the animal turned back to the supine position for 1 hour (S2).ResultsAfter instillation of the PFC, the PaO2 significantly increased from 992 +/- 32.6 mmHg at baseline to 198.1 +/- 59.2 mmHg at S1 (p = 0.001). When the dogs were turned to the prone position, the PaO2 further increased to 288.3 +/- 80.9 mmHg at P1 (p = 0.008 vs. S1): this increase was maintained for 3 hours, but the PaO2 decreased to 129.4 +/- 62.5 mmHg at S2 (p < 0.001 vs. P3). Similar changes were seen in the shunt fraction. There were no significant differences for the systemic hemodynamic parameters between the prone and supine positions.ConclusionProlonged prone positioning during PLV in an animal model of ALI appears to improve oxygenation without any hemodynamic compromise.

14 keywords...

hide…