• Clin Respir J · Jan 2014

    Characteristic features of pulmonary function test, CT volume analysis and MR perfusion imaging in COPD patients with different HRCT phenotypes.

    • Li Fan, Yi Xia, Yu Guan, Tie-feng Zhang, and Shi-yuan Liu.
    • Department of Radiology, Changzheng Hospital of the Second Military Medical University, Shanghai, China.
    • Clin Respir J. 2014 Jan 1;8(1):45-54.

    IntroductionComputed tomography (CT) and magnetic resonance imaging (MRI) can provide detailed anatomic structures and quantitative function information for chronic obstructive pulmonary disease (COPD).ObjectivesTo prospectively clarify characteristics of pulmonary function test (PFT), CT volume parameters and magnetic resonance (MR) perfusion imaging in COPD patients with different high-resolution computed tomography (HRCT) phenotypes.MethodsSixty-two patients performed PFT, CT and MR perfusion imaging. COPD was classified into three phenotypes according to HRCT quantitative findings: A, E and M phenotype. Total lung volume (TLV), total emphysema volume (TEV) and emphysema index (EI) were quantitated by HRCT. In cases of perfusion defects (PDs), the shape and size were evaluated. The contrast between the normal lung and PDs was quantified by calculating their signal intensity ratio (RSI  = SIPD /SInormal ). The correlation was performed between PFT, CT and MR perfusion.ResultsThere were 42 A phenotype, 9 E phenotype and 11 M phenotype. There was significant difference in forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) between A and M phenotype (P < 0.05). TEV and EI of A phenotype (0.4 ± 0.4 L and 8.0% ± 4.3%) were lower than those of E (1.0 ± 0.3 L and 18.6% ± 3.2%) or M phenotype (0.9 ± 0.2 L and 17.5% ± 1.7%). MR perfusion images showed circumscribed or diffuse patchy PDs. RSI of A phenotype was higher than that of E phenotype (20.3% ± 8.5% vs 11.8% ± 5.4%; P = 0.006). TEV and EI were moderate negatively correlated with diffusion function parameters. RSI was strongly correlated with FEV1% (A) and FEV1/FVC (M). FEV1/FVC was strongly correlated with TEV or EI (E).ConclusionThere were different features and correlations between PFT, CT volume and MR perfusion in different phenotype, indicating each phenotype may have novel imaging method guiding clinical management.© 2013 John Wiley & Sons Ltd.

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