• Neuroscience letters · Apr 2011

    Analgesic effect of intrathecally γ-aminobutyric acid transporter-1 inhibitor NO-711 administrating on neuropathic pain in rats.

    • Yue Li, Yicong Li, Peifei Gu, Baojun Fu, Fang Liu, and Enyou Li.
    • Department of Anaesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China. liyicong2000@yahoo.com.cn
    • Neurosci. Lett. 2011 Apr 20;494(1):6-9.

    AbstractTo investigate the analgesic effect of intrathecally administered γ-aminobutyric acid (GABA) transporter-1 inhibitor NO-711 on the sciatic nerve chronic constriction injury (CCI) rats. 5 days after intrathecal catheter placement, neuropathic pain model was established by CCI of sciatic nerve on rats. Withdrawal thresholds for mechanical allodynia and latency for thermal hyperalgesia were measured in all animals. All rats operated upon for CCI displayed decreased withdrawal thresholds for mechanical allodynia and latency for thermal hyperalgesia, which has significant difference compared with sham groups. After intrathecal NO-711 administration, withdrawal thresholds and latency were significantly increased on CCI rats compared with control group after 1 day. The results show that GABA transporter-1 inhibitor could effectively develop analgesic effect in sciatic nerve CCI rats' model.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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