• Oncology nursing forum · Oct 2000

    Factors that influence a patient's decision to participate in a phase I cancer clinical trial.

    • K M Schutta and C B Burnett.
    • Hematology/Oncology Department, Georgetown University Medical Center, Washington, DC, USA. schuttak@gunet.georgetown.edu
    • Oncol Nurs Forum. 2000 Oct 1;27(9):1435-8.

    Purpose/ObjectivesTo explore factors that influence an individual's decision to participate in phase I cancer clinical trials.DesignExploratory, descriptive, and qualitative study.SettingOutpatient oncology clinic of a comprehensive cancer center in an urban setting.Sample22 patients with cancer who had been asked at some point during their treatment to participate in a phase I cancer clinical trial were invited to participate in a focus group. Eight patients participated.MethodsTwo focus groups were conducted.Main Research VariablesFactors that influenced patients' decisions to participate in a phase I cancer clinical trial.FindingsParticipants expressed that hope for a cure and trusting the oncologist's advice were the primary factors that influenced their decisions to participate in phase I research. The majority expressed surprise that anyone would participate in an experimental study for altruistic reasons.ConclusionsPatients choose to hope for some personal benefit from their participation in phase I clinical trials even though they realized that is not the purpose or goal of the trial.Implications For Nursing PracticeNurses are in an ideal position to offer information to individuals who are deciding whether to participate in a phase I cancer clinical trial. However, most nurses are not seizing this opportunity. Patients are unable to describe nurses' impact on their decision to enter a phase I cancer clinical trial.

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