• A Shimamoto, S Kanemitsu, K Fujinaga, M Takao, K Onoda, T Shimono, K Tanaka, H Shimpo, and I Yada.
• Department of Thoracic and Cardiovascular Surgery, Mie University School of Medicine, Tsu, Japan. jj6jdv@clin.medic.mie-u.ac.jp
• Ann. Thorac. Surg. 2000 Jan 1;69(1):115-20.

BackgroundThis study was designed to analyze the biocompatibility of silicone-coated oxygenators using inflammatory response as the outcome measure, and to investigate whether the silicone-coated oxygenators perform better in terms of postoperative organ dysfunction.MethodsThe 32 patients who underwent cardiopulmonary bypass (CPB) were divided into 3 groups: group A (n = 10), heparin-coated circuit with silicone-coated oxygenator; group B (n = 11), whole heparin-coated circuit; and group C (n = 11), whole untreated circuit. The plasma concentrations of the proinflammatory markers, made of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, interleukin-8), terminal complement complex (C5b-9), and polymorphonuclear elastase (PMN-E), were measured by enzyme-linked immunosorbant assay.ResultsAll proinflammatory markers were significantly lower in groups A and B than in group C, especially C5b-9 and PMN-E concentrations, which were significantly lower in group A than in group B. The alveolar-arterial oxygen gradients (A-aDO2) and the respiratory index were significantly better in group A than in group C. In group B, however, only the A-aDO2 was significantly better than in group C. The duration of intubation and the length of stay in the intensive care unit stay were significantly shorter in groups A and B than in group C.ConclusionsSilicone-coated oxygenators are biocompatible and prevent postoperative organ dysfunction.

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