• Michael J Cangelosi, Jesse D Ortendahl, Lisa M Meckley, Tanya G K Bentley, Ayanna M Anene, Kelly M Shriner, and John Fox.
• Boston Scientific Corporation, Marlborough, MA, USA.
• Expert Rev Pharmacoecon Outcomes Res. 2015 Apr 1;15(2):357-64.

ObjectivesWe examined the cost-effectiveness of treating poorly controlled, severe, persistent asthma patients with bronchial thermoplasty (BT), a novel technology that uses thermal energy to reduce airway smooth muscle mass, with 5-year outcome data demonstrating a durable reduction in asthma exacerbations.Study DesignWe conducted a model-based cost-effectiveness analysis assessing 5-year healthcare utilization, patient quality of life and adverse events.MethodsWe utilized Markov modeling to estimate the costs and quality-of-life impact of BT compared with high-dose combination therapy among poorly controlled, severe, persistent asthma patients: those requiring high-dose combination therapy and having experienced an asthma exacerbation-related ER visit in the past year.ResultsThe cost-effectiveness of BT was US$5495 per quality-adjusted life year; and approximately 22% of sensitivity analysis iterations estimated BT to reduce costs and increase quality of life.ConclusionsBT is a cost-effective treatment option for patients with poorly controlled, severe, persistent asthma.

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