• Oral Surg Oral Med Oral Pathol Oral Radiol · Dec 2013

    Improvement of peripheral nerve defects using a silicone conduit filled with hepatocyte growth factor.

    • Rahim Mohammadi, Masoume Masoumi-Verki, Sima Ahsan, Azadeh Khaleghjoo, and Keyvan Amini.
    • Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Electronic address: r.mohammadi@urmia.ac.ir.
    • Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec 1;116(6):673-9.

    ObjectiveTo assess local effects of hepatocyte growth factor (HGF) on peripheral nerve repair in a rat sciatic nerve transection model.Study DesignSixty male, healthy, white Wistar rats were randomized into 4 experimental groups: In the sham-operated group, sciatic nerve was exposed and manipulated. In the transected control group, the left sciatic nerve was transected. In the silicone graft group (SIL), a 10-mm defect was made and bridged using a silicone tube. The graft was filled with phosphate-buffered saline in the SIL group and with HGF in the SIL/HGF group.ResultsBehavioral testing, sciatic nerve functional study, gastrocnemius muscle mass measurement, and morphometric indices found earlier regeneration of axons in the SIL/HGF than in the SIL group (P < .05). Immunohistochemical study clearly found more positive location of reactions to S-100 in the SIL/HGF group than in the SIL group.ConclusionsHGF may have clinical implications for the surgical management of patients after facial nerve transection.Copyright © 2013 Elsevier Inc. All rights reserved.

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