• Stroke · Jul 2009

    Reduced platelet activity is associated with early clot growth and worse 3-month outcome after intracerebral hemorrhage.

    • Andrew M Naidech, Borko Jovanovic, Storm Liebling, Rajeev K Garg, Sarice L Bassin, Bernard R Bendok, Richard A Bernstein, Mark J Alberts, and H Hunt Batjer.
    • Department of Neurology, Northwestern University, Chicago, IL 60611, USA. a-naidech@northwestern.edu
    • Stroke. 2009 Jul 1;40(7):2398-401.

    Background And PurposeAntiplatelet medication use and reduced platelet activity may be associated with mortality after intracerebral hemorrhage (ICH). We tested the hypothesis that reduced platelet activity is associated with early ICH clot growth and worse outcomes.MethodsWe prospectively identified patients with spontaneous ICH, measured platelet activity (VerifyNow-ASA, Accumetrics) on admission, and recorded antiplatelet medication use. ICH volume was calculated using computerized volumetric analysis. Data were analyzed with nonparametric statistics and repeated measures ANOVA as appropriate. Patients were prospectively followed for functional outcomes. Data are presented as mean+/-SD or median [Q1 to Q3].ResultsReduced platelet activity (ConclusionsReduced platelet activity was associated with early ICH volume growth and worse functional outcome. Because platelet activity can be increased with platelet transfusion, increasing platelet activity is a potential method to reduce ICH volume growth and improve functional outcomes.

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