• Stem Cell Res Ther · Jan 2011

    Editorial

    Amyloid precursor protein: more than just neurodegeneration.

    • Sanjay W Pimplikar and Kaushik Ghosal.
    • Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, NC-30, Cleveland, OH 44195, USA. pimplis@ccf.org
    • Stem Cell Res Ther. 2011 Jan 1;2(5):39.

    AbstractAmyloid precursor protein (APP) fascinates cell biologists because it is proteolytically processed to generate multiple peptides, including amyloid-β, which is implicated in Alzheimer's disease. However, a large body of data also shows that the extracellular soluble fragment of APP produced by α-secretase (sAPPα) is neuroprotective and promotes neuronal outgrowth. A study by Demars and colleagues appearing in the previous issue provides data showing that sAPPα is a general growth factor for stem cells of multiple lineages. Thus, APP seems to play complex and disparate roles in neurodegeneration and neuroprotection.

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