Randomized Controlled Trial
Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.
JAMA. 2000 Jan 19;283(3):367-72.
Review
Naloxegol: a review of its use in patients with opioid-induced constipation.
Drugs. 2015 Mar 1;75(4):419-25.
Randomized Controlled Trial
Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study.
J Pain. 2011 May 1;12(5):554-62.