• Clin. Infect. Dis. · Oct 2014

    Extensive drug resistance acquired during treatment of multidrug-resistant tuberculosis.

    • J Peter Cegielski, Tracy Dalton, Martin Yagui, Wanpen Wattanaamornkiet, Grigory V Volchenkov, Laura E Via, Martie Van Der Walt, Thelma Tupasi, Sarah E Smith, Ronel Odendaal, Vaira Leimane, Charlotte Kvasnovsky, Tatiana Kuznetsova, Ekaterina Kurbatova, Tiina Kummik, Liga Kuksa, Kai Kliiman, Elena V Kiryanova, HeeJin Kim, Chang-ki Kim, Boris Y Kazennyy, Ruwen Jou, Wei-Lun Huang, Julia Ershova, Vladislav V Erokhin, Lois Diem, Carmen Contreras, Sang Nae Cho, Larisa N Chernousova, Michael P Chen, Janice Campos Caoili, Jaime Bayona, Somsak Akksilp, and Global Preserving Effective TB Treatment Study (PETTS) Investigators.
    • Centers for Disease Control and Prevention, Atlanta, Georgia.
    • Clin. Infect. Dis. 2014 Oct 15;59(8):1049-63.

    BackgroundIncreasing access to drugs for the treatment of multidrug-resistant (MDR) tuberculosis is crucial but could lead to increasing resistance to these same drugs. In 2000, the international Green Light Committee (GLC) initiative began to increase access while attempting to prevent acquired resistance.MethodsTo assess the GLC's impact, we followed adults with pulmonary MDR tuberculosis from the start to the end of treatment with monthly sputum cultures, drug susceptibility testing, and genotyping. We compared the frequency and predictors of acquired resistance to second-line drugs (SLDs) in 9 countries that volunteered to participate, 5 countries that met GLC criteria, and 4 countries that did not apply to the GLC.ResultsIn total, 832 subjects were enrolled. Of those without baseline resistance to specific SLDs, 68 (8.9%) acquired extensively drug-resistant (XDR) tuberculosis, 79 (11.2%) acquired fluoroquinolone (FQ) resistance, and 56 (7.8%) acquired resistance to second-line injectable drugs (SLIs). The relative risk (95% confidence interval [CI]) of acquired resistance was lower at GLC-approved sites: 0.27 (.16-.47) for XDR tuberculosis, 0.28 (.17-.45) for FQ, and 0.15 (.06-.39) to 0.60 (.34-1.05) for 3 different SLIs. The risk increased as the number of potentially effective drugs decreased. Controlling for baseline drug resistance and differences between sites, the odds ratios (95% CIs) were 0.21 (.07-.62) for acquired XDR tuberculosis and 0.23 (.09-.59) for acquired FQ resistance.ConclusionsTreatment of MDR tuberculosis involves substantial risk of acquired resistance to SLDs, increasing as baseline drug resistance increases. The risk was significantly lower in programs documented by the GLC to meet specific standards.Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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