• Br J Clin Pract · Sep 1996

    Case Reports

    Acute psychosis associated with abrupt withdrawal of carbamazepine following intoxication.

    • D Darbar, A M Connachie, A M Jones, and R W Newton.
    • Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
    • Br J Clin Pract. 1996 Sep 1;50(6):350-1.

    AbstractCarbamazepine is regularly used in the treatment of trigeminal neuralgia. Although exacerbation of psychosis has been described following abrupt discontinuation of carbamazepine in chronic schizophrenics, a withdrawal syndrome has not been reported previously in patients treated for trigeminal neuralgia. The case presented here suggests that abrupt withdrawal of toxic concentrations of carbamazepine may precipitate a withdrawal reaction, which is manifest some days after discontinuation of the drug. Therefore it may be advisable to withdraw therapy slowly in these situations.

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