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- Michael A Flierl, Heike Schreiber, and Markus S Huber-Lang.
- Department of Traumatology, Hand and Reconstructive Surgery, University Hospital of Ulm, Steinhoevelstrasse 9, 89075 Ulm, Germany.
- J Invest Surg. 2006 Jul 1;19(4):255-65.
AbstractSepsis continues to be a major clinical problem that is difficult to treat, as the pathophysiology of the disease is still unclear. Despite promising experimental strategies, therapeutic interventions have been largely unsuccessful. There is now increasing evidence that the disturbance of innate immunity during sepsis and multiorgan dysfunction syndrome (MODS) may be linked to uncontrolled activation of the complement system. Especially, the powerful anaphylatoxin C5a seems to play a key role in the development of immune paralysis. In this review, we describe our present understanding of the role of complement in the inflammatory response during sepsis and MODS.
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