• Xin Wang, Li Jiang, Ying Wen, Mei-Ping Wang, Wei Li, Zhi-Qiang Li, and Xiu-Ming Xi.
• Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, Beijing 100038, China ; Department of Surgical Intensive Care Units, Hepatobiliary Surgery and Liver Transplant Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
• Biomed Res Int. 2014 Jan 1;2014:172620.

ObjectiveTo discover risk factors for mortality of patients with septic AKI in ICU via a multicenter study.BackgroundSeptic AKI is a serious threat to patients in ICU, but there are a few clinical studies focusing on this.MethodsThis was a prospective, observational, and multicenter study conducted in 30 ICUs of 28 major hospitals in Beijing. 3,107 patients were admitted consecutively, among which 361 patients were with septic AKI. Patient clinical data were recorded daily for 10 days after admission. Kidney Disease: Improving Global Outcomes (KDIGO) criteria were used to define and stage AKI. Of the involved patients, 201 survived and 160 died.ResultsThe rate of septic AKI was 11.6%. Twenty-one risk factors were found, and six independent risk factors were identified: age, APACHE II score, duration of mechanical ventilation, duration of MAP <65 mmHg, time until RRT started, and progressive KIDGO stage. Admission KDIGO stages were not associated with mortality, while worst KDIGO stages were. Only progressive KIDGO stage was an independent risk factor.ConclusionsSix independent risk factors for mortality for septic AKI were identified. Progressive KIDGO stage is better than admission or the worst KIDGO for prediction of mortality. This trial is registered with ChiCTR-ONC-11001875.

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