• The American surgeon · Mar 2012

    Review Meta Analysis

    Antibiotic prophylaxis in patients undergoing open mesh repair of inguinal hernia: a meta-analysis.

    • Yuan Yin, Turun Song, Banghua Liao, Qian Luo, and Zongguang Zhou.
    • Center of Gastrointestinal Surgery, Sichuan University, Chengdu, China.
    • Am Surg. 2012 Mar 1;78(3):359-65.

    AbstractThe use of antibiotic prophylaxis in hernia repair is still under debate. The aim of this meta-analysis was to assess the effect of antibiotic prophylaxis in patients undergoing open mesh repair of inguinal hernia with respect to incidence of postoperative surgical site infection (SSI). A literature search was conducted in databases of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials. Study selection, data extraction, quality assessment, and meta-analysis were conducted according to the recommendations by Cochrane collaboration. Nine randomized controlled trials were included. Incidence of surgical site infection was 39/1642 (2.38%) in the antibiotic group and 70/1676 (4.18%) in the control group. Antibiotics showed a protective effect in preventing SSI after mesh inguinal hernia repair (odds ratio: 0.61, 95% confidence interval: 0.40-0.92, I(2): 0%). Antibiotic prophylaxis did reduce the incidence of SSI in hernia patients undergoing mesh hernioplasty. The cost effectiveness of antibiotic prophylaxis needs further evaluation.

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