• Phys Med Rehabil Clin N Am · May 2014

    Review

    Opioid syndrome: failed opioid therapy for chronic noncancer pain.

    • Leonard B Kamen and Kristofer J Feeko.
    • MossRehab Outpatient Center, Albert Einstein Healthcare Network, 9880 Bustleton Avenue, Suite 309, Philadelphia, PA 19115, USA; Department of Physical Medicine and Rehabilitation, Temple University Hospital, Philadelphia, PA, USA. Electronic address: lkamen@einstein.edu.
    • Phys Med Rehabil Clin N Am. 2014 May 1;25(2):375-95.

    AbstractTreatment of chronic noncancer pain (CNCP) with high-dose opioids (HDOs) has burgeoned over the past 2 decades in the United States. Characteristic domains and features of the failed CNCP management patient using long-term HDOs are described herein as the/an opioid syndrome (Schreiber AL, personal communication. 2013). Reversing or even modulating HDO use in patients with CNCP requires a paradigm shift on the part of physician, patient, and the societal "quick fix" medical culture. This review offers measures, agents, and strategies to consider in management of this pervasive, erosive medical and societal challenge.Copyright © 2014 Elsevier Inc. All rights reserved.

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