• Transplant. Proc. · Jul 2006

    Effects of ulinastatin on postoperative systemic inflammatory response of recipients of rat small bowel transplantation.

    • J-L Sun, X-Q Zhang, Z-G Yu, R Ma, Y Dai, Z-Y Fan, and J-Z Sun.
    • Department of Operation, Qilu Hospital of Shandong University, Shandong, China.
    • Transplant. Proc. 2006 Jul 1;38(6):1803-4.

    AimWe sought to evaluate the effects of ulinastatin on postoperative systemic inflammatory responses of recipients of rat small bowel transplantations (SBT).MethodsTwenty-four recipients of rat heterotopic SBT were randomly divided into a control group and a treated group. Ulinastatin (50,000 U/kg(-1)/d(-1)) was injected intravenously 30 minutes before graft revascularization. Measured variables included plasma concentrations of tumor necrosis factor (TNF), interleukin (IL)-6, and C-reactive protein (CRP) on postoperative days 1 and 3.ResultsAdministration of ulinastatin attenuated the postoperative increases in plasma concentrations of TNF, IL-6, and CRP.ConclusionUlinastatin attenuated the postoperative systemic inflammatory response of rat recipients of SBT.

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