• Jesús González-Barboteo, Xavier Gómez-Batiste Alentorn, Felipe A Calvo Manuel, Vicente Alberola Candel, M Amalia Palacios Eito, Isabel Sánchez-Magro, Marta Neira Álvarez, F Javier Pérez Martín, and Josep Porta-Sales.
• Palliative Care Service, Hospital Duran I Reynals, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; Chair of Palliative Care, Center for Health and Social Studies, University of Vic., Barcelona, Spain; Palliative Care Research Group, IDIBELL, Universitary Bellvitge Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
• J Opioid Manag. 2014 Nov 1;10(6):395-403.

ObjectiveTo assess the effectiveness of opioid rotation (OR) to manage cancer pain. To describe the adverse events (AEs) associated with OR.SettingThirty-nine tertiary hospital services.PatientsSixty-seven oncological patients with cancer-related pain treated at outpatient clinics.InterventionProspective multicenter study. Pain intensity was scored using a Numerical Rating Scale (NRS) of 0-10. Average pain (AP) intensity in the last 24 hours, breakthrough pain (BTP), and the number of episodes of BTP on the days before and 1 week after OR were assessed. The pre-OR and post-OR opioid were recorded. The presence and intensity of any AEs occurring after OR were also recorded.ResultsIn the 67 patients evaluated, 75 ORs were recorded. In all cases, the main reason for OR was poor pain control. Pain intensity decreased by ≥2 points after OR in 75.4 percent and 57.8 percent of cases for AP and BTP, respectively. If the initial NRS score was ≥4, a decrease below <4 accounted for 50.9 percent and 32.3 percent of cases for AP and BTP, respectively. The number of episodes of BTP also decreased significantly (p<0.001). A total of 107 AEs were reported, most of which were mild in intensity, with gastrointestinal symptoms predominating.ConclusionsOpioid rotation appears to be both safe and effective in the management of basal and breakthrough cancer pain.

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