• Imran H Iftikhar, Erin Rikard Hays, Michelle-Anne Iverson, Ulysses J Magalang, and Andrea Kay Maas.
• University of South Carolina, School of Medicine, Columbia, SC, USA. Imran.Iftikhar@uscmed.sc.edu
• J Clin Sleep Med. 2013 Feb 15;9(2):165-74.

BackgroundObstructive sleep apnea (OSA) is an independent risk factor for the development of hypertension. However the effect of continuous positive airway pressure (CPAP) on lowering systemic blood pressure (BP) in OSA patients has been conflicting. Oral appliance (OA) therapy is an important alternative therapy to CPAP for patients with mild to moderate OSA.ObjectiveTo conduct a meta-analysis of studies which have evaluated the effect of OAs on BP in patients with OSA.Data SourcesStudies were retrieved by searching PubMed (all studies that were published until December 15, 2011)Study SelectionThree independent reviewers screened citations to identify trials of the effect of OA on BP.Data ExtractionData from observational and randomized controlled trial (RCT) studies was extracted for pre- and post-treatment systolic, diastolic, and mean arterial blood pressure (SBP, DBP, and MAP).Data SynthesisA total of 7 studies that enrolled 399 participants met the inclusion criteria. The pooled estimate of mean changes and the corresponding 95% CIs for SBP, DBP, and MAP from each trial are -2.7 mm Hg (95% CI: -0.8 to -4.6), p-value 0.04; -2.7 mm Hg (95% CI: -0.9 to -4.6), p-value 0.004; and -2.40 mm Hg (95% CI: -4.01 to -0.80), p-value 0.003 (Figures 2-4). The pooled estimate of mean changes and the corresponding 95% CIs for nocturnal SBP, DBP, and MAP from each trial are -2.0 mm Hg (95% CI: 1.1 to -5.3), p-value 0.212; -1.7 mm Hg (95% CI: -0.1 to -3.2), p-value 0.03; and -1.9 mm Hg (95% CI: 1.3 to -5.1), p-value 0.255 (Figures 5-7) respectively.ConclusionsThe pooled estimate shows a favorable effect of OAs on SBP, MAP, and DBP. Most of the studies were observational. Therefore, more RCTs are warranted involving a larger number of patients and longer treatment periods to confirm the effects of OA on BP.

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