• Eur J Anaesthesiol · Mar 2006

    Randomized Controlled Trial Comparative Study

    Antipruritic and antiemetic effect of epidural droperidol: comparative study between single and continuous epidural injection.

    • I H Lee and I O Lee.
    • Department of Anesthesiology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    • Eur J Anaesthesiol. 2006 Mar 1;23(3):213-8.

    Background And ObjectivesThis study was designed to investigate whether single epidural droperidol or continuous epidural droperidol inhibit pruritus and postoperative nausea and vomiting induced by postoperative continuous epidural fentanyl administration, and to identify the optimal method of administering epidural droperidol.Methods120 ASA I-II patients undergoing subtotal gastrectomy with general anaesthesia combined with epidural anaesthesia were randomly allocated into three groups: control (no droperidol), single injection (droperidol 2.5 mg) and continuous group (droperidol 2.5 mg 2 day(-1)). Postoperatively the frequency and severity of pruritus and postoperative nausea and vomiting in all groups were compared during 48 h.ResultsThe frequency and severity of pruritus was significantly lower in both single injection and continuous groups than control group after epidural fentanyl administration (P < 0.05). The frequency and severity of postoperative nausea and vomiting was significantly lower in single injection group than control group after epidural fentanyl administration (P < 0.05).ConclusionEpidural continuous droperidol is effective for reducing pruritus, and single epidural droperidol injection is effective for reducing pruritus and postoperative nausea and vomiting induced by postoperative continuous epidural fentanyl analgesia.

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