• Transfus Apher Sci · Feb 2008

    Review

    Evidence-based use of recombinant FVIIa (NovoSeven, NiaStase) for the treatment of hemophilia with inhibitors in children and adolescents.

    • Brahm Goldstein, Brian Geldziler, Jens Bjerre, and Stephanie Seremetis.
    • Novo Nordisk Inc., 100 College Road West, Princeton, NJ, United States. bgol@novonordisk.com
    • Transfus Apher Sci. 2008 Feb 1;38(1):25-32.

    AbstractChildren and adolescents comprise a significant proportion of the hemophilia population, including those patients who have developed inhibitors to factor VIII or FIX. We examine the use of rFVIIa for the treatment of bleeding episodes and the prevention of bleeding in children and adolescents with hemophilia A and B with inhibitors, focusing on registry data and recent clinical trial results. Based on this review of the literature, we conclude that recombinant FVIIa is safe and effective for use in controlling bleeding in these patient populations.

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