• Br J Anaesth · Apr 1975

    The effect of seven vasopressors of halothane MAC in dogs.

    • E P Steffey and E I Eger.
    • Br J Anaesth. 1975 Apr 1;47(4):435-8.

    AbstractWe evaluated the effects of ephedrine, mephentermine, metaraminol, phenylephrine, methoxamine, noradrenaline and adrenaline on halothane anaesthetic requirement (MAC) in dogs. MAC increased significantly only during ephedrine infusion (50%) although significance was approached with mephentermine (21%). Phenylephrine, metaraminol, methoxamine, noradrenaline and adrenaline did not change MAC. Arterial pressure was increased 50-100% with all agents. Our results support the hypothesis that anaesthetic requirement may be related, in part, to release of brain noradrenaline.

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