• Enzo Vettorato, Annalisa Zonca, Maurizio Isola, Roberto Villa, Martina Gallo, Giuliano Ravasio, Michela Beccaglia, Clara Montesissa, and Petra Cagnardi.
• Department of Veterinary Clinical Sciences, University of Padua, Agripolis, I 35020 Legnaro, Italy.
• Vet. J. 2010 Mar 1;183(3):310-5.

AbstractTramadol is a synthetic opioid agonist used extensively in human and, to a lesser extent, veterinary medicine throughout the world. The clinical efficacy and pharmacokinetic profile of intravenous (i.v.) and extradural (e.d.) tramadol (2 mg/kg) and its o-desmethyl metabolite were studied in dogs undergoing tibial plateau levelling osteotomy (TPLO). Intra-operative cardiorespiratory variables were monitored and post-operative pain was assessed using the short form of the Glasgow Composite Pain Scale. A rapid (<5 min) and effective production of o-desmethyl tramadol was recorded. The pharmacokinetic profile was similar for tramadol and its metabolite irrespective of the route of administration. E.d. tramadol provided sufficient intra- and post-operative analgesia without significant clinical side-effects, but the post-operative analgesia was comparable to that following i.v. administration and the e.d. route could therefore not be considered a practical alternative to the i.v. route.2008 Elsevier Ltd. All rights reserved.

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