• Haemophilia · Nov 2000

    Case Reports

    Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy.

    • R Parameswaran, J P Dickinson, S de Lord, D M Keeling, and B T Colvin.
    • Haemophilia Centre, St Bartholomew's and The London NHS Trust, Royal London Hospital, London, UK.
    • Haemophilia. 2000 Nov 1;6(6):705-8.

    AbstractCongenital afibrinogenaemia and hypofibrinogenaemia are rare disorders of haemostasis. In this case report the problems posed in the management of two patients with fibrinogen levels less than 0.1g L(-1) and who developed intracranial bleeding are considered. The value of fibrinogen concentrate and the role of prophylaxis is also discussed.

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