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- R F Clark and M V Vance.
- Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona.
- Ann Emerg Med. 1992 Mar 1;21(3):318-21.
AbstractDiphenhydramine poisoning is characterized most often by anticholinergic effects. Cardiotoxicity and circulatory collapse have rarely been reported after massive ingestions of diphenhydramine and other H1-receptor-blocking agents, although these substances have local anesthetic properties and have been studied as antiarrhythmics. We report the case of a patient who developed a wide-complex tachycardia as a complication of acute diphenhydramine poisoning that responded to IV sodium bicarbonate.
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