• Liver Int. · Jun 2003

    Comparative Study

    Direct measurement of hepatic tissue hypoxia by using a novel tcpO2/pCO2 monitoring system in comparison with near-infrared spectroscopy.

    • Wenxuan Yang, Tariq Hafez, Cecil S Thompson, Dimitri P Mikhailidis, Brain R Davidson, Marc C Winslet, and Alexander M Seifalian.
    • Hepatic Heamodynamic Laboratory, University Department of Surgery and Transplantation, Royal Free and University College Medical School, University College London, Royal Free Hospital, London, UK.
    • Liver Int. 2003 Jun 1;23(3):163-70.

    Background/AimsHepatic hypoxia occurs during liver surgery and transplantation and it may also appear within liver tumours, correlating with prognosis and efficacy of the treatment. The present study measured liver tissue hypoxia by directly using near-infrared spectroscopy (NIRS) and a novel tcpO2/pCO2 monitoring system.MethodsGraded hypoxia was achieved in a rabbit model by a stepwise reduction of the fraction of inspired oxygen (FiO2) from 0.3 to 0.0. Animals were allowed to recover from hypoxia at FiO2 of 3.0 indicated by normalised arterial blood gas values. Hepatic tissue oxyhaemoglobin (HbO2), deoxyhaemoglobin (Hb), cytochrome oxidase (Cyt Ox), oxygen partial pressure (pO2) and carbon dioxide partial pressure (pCO2) were measured continuously with the help of NIRS and a Clark-type surface tcpO2/pCO2 monitoring system, throughout the period of hypoxaemia.ResultsThere was an immediate reduction in hepatic HbO2 with hypoxia and a simultaneous increase in hepatic Hb. Similarly, hepatic tissue pO2 decreased significantly but tissue pCO2 remained unchanged until the FiO2 was below 0.1. Hepatic HbO2 showed a positive correlation with tissue pO2 (r = 0.53, P < 0.001). Hepatic Hb showed a negative correlation with tissue pO2 (r = 0.47, P < 0.001). Hepatic Cyt Ox decreased significantly with an FiO2 of 0.1 or less and showed a positive correlation with hepatic tissue pO2 (r = 0.64, P < 0.001). A significant correlation was found between hepatic tissue pO2 and arterial blood pO2 (r = 0.44, P < 0.001). Arterial blood pCO2 also correlated with hepatic tissue pCO2 (r = 0.53, P < 0.001) measured by the tcpO2/pCO2 monitoring system.ConclusionThe data from the present study suggest that, like NIRS, the tcpO2/pCO2 monitoring system can be reliably used for the direct monitoring of hepatic tissue oxygenation in vivo.

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