• Médecine sciences : M/S · Apr 2004

    Review

    [Anchoring proteins and cardiac sudden death: how and why?].

    • Marc Pourrier and Stanley Nattel.
    • Département de pharmacologie et Centre de recherche, Université de Montréal, Québec, Canada.
    • Med Sci (Paris). 2004 Apr 1;20(4):437-41.

    AbstractMutations in proteins responsible for ion transport in cardiac tissue can induce a destabilization of electrical function and provoke cardiac sudden death. Identification of a genetic anomaly in a French family that developed the syndrome of cardiac sudden death has revealed a crucial new element in normal cardiac electrical function : Ion channels need to be anchored to specific domains at the plasma membrane by an anchoring protein called ankyrin-B.

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