• Lancet · Aug 1975

    Randomized Controlled Trial Comparative Study Clinical Trial

    Comparison of 5-day, 1-day, and 2-day cyclical combination chemotherapy in advanced breast cancer.

    • G A Edelstyn, T D Bates, D Brinkley, K D MacRae, M F Spittle, and T Wheeler.
    • Lancet. 1975 Aug 2;2(7927):209-11.

    AbstractThe results of 5-day cyclical combined chemotherapy for advanced breast cancer were compared in two trials with the less demanding 1-day and 2-day regimens. At all stages, except at 3 months, 5-day treatment was significantly more successful in providing regression and remission of tumours than the 1-day regimen. However, although the differences are not statistically significant, data from the second trial indicated that the 2-day regimen tended to be more effective than the 5-day regimen. The lower 95% confidence limit for the success of the 2-day treatment was 56.2% at 3 months.

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