• Yutaka Hirashima, Masanori Kurimoto, Nakamasa Hayashi, Kimiko Umemura, Emiko Hori, Hideki Origasa, and Shunro Endo.
• Department of Neurosurgery, Toyama Medical and Pharmaceutical University, 2630 Sugutani, Toyama 930-0194, Japan. yhira@ms.toyama-mpu.ac.jp
• Neurol. Med. Chir. (Tokyo). 2005 Apr 1;45(4):177-82; discussion 182-3.

AbstractThe optimal duration of cerebrospinal fluid (CSF) drainage after acute aneurysm surgery is unclear. The association between the occurrence of symptomatic vasospasm or late hydrocephalus and the duration of CSF drainage was investigated using multiple logistic analysis in 95 consecutive patients with aneurysmal subarachnoid hemorrhage who underwent surgery within 72 hours after onset. The duration of drainage was significantly related to the occurrence of symptomatic vasospasm and late hydrocephalus. The cut-off values of the duration of drainage for preventing symptomatic vasospasm and late hydrocephalus were 11 days (adjusted odds ratio 0.347, 95% confidence interval 0.135-0.889, p = 0.0274) and 6 days (adjusted odds ratio 4.86, 95% confidence interval 1.46-16.2, p = 0.0099), respectively. Prevention of both symptomatic vasospasm and late hydrocephalus is not possible without additional procedures such as cisternal irrigation using fibrinolytic agents.

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