• Antimicrob. Agents Chemother. · Aug 2012

    Randomized Controlled Trial

    Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine.

    • Simbarashe P Zvada, Paolo Denti, Hennie Geldenhuys, Sandra Meredith, Danelle van As, Mark Hatherill, Willem Hanekom, Lubbe Wiesner, Ulrika S H Simonsson, Amina Jindani, Thomas Harrison, and Helen M McIlleron.
    • Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
    • Antimicrob. Agents Chemother. 2012 Aug 1;56(8):4471-3.

    AbstractWe described the population pharmacokinetics of moxifloxacin and the effect of high-dose intermittent rifapentine in patients with pulmonary tuberculosis who were randomized to a continuation-phase regimen of 400 mg moxifloxacin and 900 mg rifapentine twice weekly or 400 mg moxifloxacin and 1,200 mg rifapentine once weekly. A two-compartment model with transit absorption best described moxifloxacin pharmacokinetics. Although rifapentine increased the clearance of moxifloxacin by 8% during antituberculosis treatment compared to that after treatment completion without rifapentine, it did not result in a clinically significant change in moxifloxacin exposure.

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