• Walid Abdel Wahab Mohamed and Mohamed Abdullatif Saeed.
• Department of Pediatrics, King Khalid University, Abha, Saudi Arabia. walidabdo2020@gmail.com
• J. Matern. Fetal. Neonatal. Med. 2012 Apr 1;25(4):411-4.

ObjectiveTo evaluate mannose-binding lectin (MBL) serum levels as a marker for predicting sepsis, septic shock, and their outcomes in neonates.Patients And MethodsA prospective study was conducted on 62 neonates (27 preterm and 35 full term) with culture-proven sepsis and 35 controls. Serum levels of MBL were measured by immunoassay.ResultsOf 62 infants with positive blood cultures (Gram-negative = 44 and Gram-positive = 18), 11 infants had severe sepsis and 6 neonates developed septic shock. MBL levels were significantly lower in infants with sepsis than in control group (0.39 ± 0.07 vs. 1.34 ± 0.03 μg/ml; p < 0.001). The lowest MBL levels were detected in those infants with septic shock, particularly those who died (p < 0.05). MBL had high sensitivity (96.7), specificity (97.1), positive (98.3), and negative (94.4) predictive values to detect sepsis.ConclusionLow MBL serum levels could be considered as sensitive and specific marker for predicting sepsis, septic shock, and their clinical outcomes in newborn infants.

48 keywords...

hide…