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Acta Anaesthesiol Scand · Apr 2014
ReviewEtomidate - a review of robust evidence for its use in various clinical scenarios.
- G Erdoes, R M Basciani, and B Eberle.
- Department of Anaesthesiology and PainTherapy, University Hospital Bern, Bern, Switzerland.
- Acta Anaesthesiol Scand. 2014 Apr 1; 58 (4): 380-9.
AbstractEtomidate is an intravenous hypnotic with a favourable clinical profile in haemodynamic high-risk scenarios. Currently, there is an active debate about the clinical significance of the drug's side effects and its overall risk-benefit ratio. Etomidate-induced transient adrenocortical suppression is well documented and has been associated with increased mortality in sepsis. In surgical patients at risk of hypotensive complications, however, a review of current literature provides no robust evidence to contraindicate a single-bolus etomidate induction. Large randomised controlled trials as well as additional observational data are required to compare safety of etomidate and its alternatives. © 2014 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
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