• Science · Jun 1976

    Analgesia mediated by a direct spinal action of narcotics.

    • T L Yaksh and T A Rudy.
    • Science. 1976 Jun 25;192(4246):1357-8.

    AbstractNarcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone. The narcotics, acting only at the spinal level, changed cord function to block not only spinal reflexes but also the operant response to painful stimuli.

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