• Takayuki Kitamura, Gaku Kawamura, Makoto Ogawa, and Yoshitsugu Yamada.
• Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655.
• Masui. 2009 Jan 1;58(1):81-4.

BackgroundRecent studies have shown that sevoflurane impairs glucose tolerance, but the effect of propofol on glucose metabolism is not still clear.MethodsTwo hundred and seventeen patients were enrolled in this retrospective study. Patients were classified into two groups according to anesthetic agent used for maintenance of general anesthesia; sevoflurane group (n = 154) and propofol group (n = 63). Changes in blood glucose levels were compared between the two groups in four periods during anesthetic management ; within 1 hour, 1-2 hour, 2-3 hour, 3-4 hour after the induction of general anesthesia.ResultsThe two groups were comparable with regard to patients' age, gender, height, weight, and American Society of Anesthesiologists physical status. In all time periods, blood glucose level in sevoflurane group was significantly higher than that in propofol group.ConclusionsResults in this study imply that the effect on glucose metabolism of propofol is much less than that of sevoflurane.

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