• Tor D Wager, James K Rilling, Edward E Smith, Alex Sokolik, Kenneth L Casey, Richard J Davidson, Stephen M Kosslyn, Robert M Rose, and Jonathan D Cohen.
• Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109-1109, USA. torw@umich.edu
• Science. 2004 Feb 20;303(5661):1162-7.

AbstractThe experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations. Thus, placebo treatments that have no intrinsic pharmacological effects may produce analgesia by altering expectations. However, controversy exists regarding whether placebos alter sensory pain transmission, pain affect, or simply produce compliance with the suggestions of investigators. In two functional magnetic resonance imaging (fMRI) experiments, we found that placebo analgesia was related to decreased brain activity in pain-sensitive brain regions, including the thalamus, insula, and anterior cingulate cortex, and was associated with increased activity during anticipation of pain in the prefrontal cortex, providing evidence that placebos alter the experience of pain.

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