• Wen-Hsien Lu, Kai-Sheng Hsieh, Pei-Jung Lu, Yi-Shan Wu, Wen-Yu Ho, Chi-Cheng Lai, Michael Hsiao, Ching-Jiunn Tseng, and Pei-Wen Cheng.
• From the Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C. (W.-H.L., C.-J.T.); Department of Pediatrics (W.-H.L., K.-S.H.), Department of Medical Education and Research (Y.-S.W., P.-W.C., C.-J.T.), and Department of Cardiovascular Center (C.-C.L.), Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.; Graduate Institute of Aerospace and Undersea Medicine (W.-H.L.), and Department of Pharmacology (C.-J.T.), National Defense Medical Center, Taipei, Taiwan, R.O.C.; Institute of Clinical Medicine, National Cheng-Kung University, Tainan, Taiwan, R.O.C. (P.-J.L.); Division of General Internal Medicine, Department of Internal Medicine, Kaoshiung Medical University Hospital, Kaoshiung Medical University, Kaohsiung, Taiwan, R.O.C. (W.-Y.H.); Genomics Research Center, Academia Sinica, Taipei, Taiwan, R.O.C. (M.H.); and Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C. (C.-C.L., C.-J.T.).
• Anesthesiology. 2014 May 1;120(5):1192-204.

BackgroundBilateral lesions of nucleus tractus solitarii in rat result in acute hypertension, pulmonary edema, and death within hours. The hypertension results from excessive catecholamine release. Catecholamine can activate connexin43 to regulate cell death. There is no study investigating the cardiopulmonary impacts of different adrenergic blockers and apoptosis mechanism in rat model.MethodsThe authors microinjected 6-hydroxydopamine into nucleus tractus solitarii of the rat (n = 8 per group) and evaluated the cardiopulmonary changes after treatment with different concentrations of α1-blockers, α2-blockers, β-blockers, and α-agonists.ResultsIn the rat model, the authors found that prazosin (0.15 mg/kg) treatment could preserve cardiac output and reverse neutrophil infiltrations in lungs and lead to prevent pulmonary hemorrhagic edema. The time-dependent increases in connexin43 and terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells induced by 6-hydroxydopamine lesions were decreased after prazosin treatment (terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells at 6 h: 64.01 ± 2.41% vs. 24.47 ± 3.10%; mean ± SD, P < 0.001, in heart, and 80.83 ± 2.52% vs. 2.60 ± 1.03%, P < 0.001, in lung). However, propranolol caused further compromise of the already impaired cardiac output with consequence of rapid death. Phenylephrine enhanced the phenotype in the link between connexin43 expressions and terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells but not yohimbine. Connexin43 expressions and terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells were more decreased with prazosin (0.15 and 0.3 mg/kg) than that with prazosin (0.05 mg/kg) treatment.Conclusionsα1-Receptors are the keystones of the phenotype. In some brainstem encephalitis and brain injury with nucleus tractus solitarii involvement, early α1-receptor blockade treatment may prevent acute death from tissue apoptosis. α-Blockers can also decrease cerebral perfusion pressure, and further studies are needed in translation to brain injury with increased intracranial pressure.

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