• Acta paediatrica · Jul 2012

    Case Reports

    Effects of naloxone on the breathing pattern of a newborn exposed to maternal opiates.

    • Jeroen J van Vonderen, Melissa L Siew, Stuart B Hooper, Marjon A de Boer, Frans J Walther, and Arjan B te Pas.
    • Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, The Netherlands. j.j.van_vonderen@lumc.nl
    • Acta Paediatr. 2012 Jul 1;101(7):e309-12.

    AimTo give new insights into how an infant responded to naloxone, given after acquiring a maternal opiate by recording the breathing pattern directly after birth.MethodA respiratory recording is presented of an infant during resuscitation in the delivery room after receiving naloxone for respiratory depression, resulting from maternal remifentanyl use.ResultsThe infant was born apneic and bradycardic. Normal resuscitation manoeuvres had no effect on the respiratory drive. Directly after administration of naloxone, a tachypneic breathing pattern with sporadic expiratory breaking manoeuvres was observed.ConclusionThe immediate tachypnoea is most likely a direct effect of the naloxone causing an immediate 'rebound response' after the release of the opiate-induced inhibition of the respiratory drive.© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

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