• Colin Studholme, Corina Drapaca, Bistra Iordanova, and Valerie Cardenas.
• Department of Radiology, University of California San Francisco, Northern California Institute for Research and Education, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA. colin.studholme@ieee.org
• IEEE Trans Med Imaging. 2006 May 1;25(5):626-39.

AbstractThis paper is motivated by the analysis of serial structural magnetic resonance imaging (MRI) data of the brain to map patterns of local tissue volume loss or gain over time, using registration-based deformation tensor morphometry. Specifically, we address the important confound of local tissue contrast changes which can be induced by neurodegenerative or neurodevelopmental processes. These not only modify apparent tissue volume, but also modify tissue integrity and its resulting MRI contrast parameters. In order to address this confound we derive an approach to the voxel-wise optimization of regional mutual information (RMI) and use this to drive a viscous fluid deformation model between images in a symmetric registration process. A quantitative evaluation of the method when compared to earlier approaches is included using both synthetic data and clinical imaging data. Results show a significant reduction in errors when tissue contrast changes locally between acquisitions. Finally, examples of applying the technique to map different patterns of atrophy rate in different neurodegenerative conditions is included.

31 keywords...

hide…