• Annals of surgery · Jun 2008

    The timing of surgical antimicrobial prophylaxis.

    • Walter P Weber, Walter R Marti, Marcel Zwahlen, Heidi Misteli, Rachel Rosenthal, Stefan Reck, Philipp Fueglistaler, Martin Bolli, Andrej Trampuz, Daniel Oertli, and Andreas F Widmer.
    • Department of General Surgery, University Hospital of Basel, Basel, Switzerland.
    • Ann. Surg. 2008 Jun 1;247(6):918-26.

    ObjectiveTo obtain precise information on the optimal time window for surgical antimicrobial prophylaxis.Summary Background DataAlthough perioperative antimicrobial prophylaxis is a well-established strategy for reducing the risk of surgical site infections (SSI), the optimal timing for this procedure has yet to be precisely determined. Under today's recommendations, antibiotics may be administered within the final 2 hours before skin incision, ideally as close to incision time as possible.MethodsIn this prospective observational cohort study at Basel University Hospital we analyzed the incidence of SSI by the timing of antimicrobial prophylaxis in a consecutive series of 3836 surgical procedures. Surgical wounds and resulting infections were assessed to Centers for Disease Control and Prevention standards. Antimicrobial prophylaxis consisted in single-shot administration of 1.5 g of cefuroxime (plus 500 mg of metronidazole in colorectal surgery).ResultsThe overall SSI rate was 4.7% (180 of 3836). In 49% of all procedures antimicrobial prophylaxis was administered within the final half hour. Multivariable logistic regression analyses showed a significant increase in the odds of SSI when antimicrobial prophylaxis was administered less than 30 minutes (crude odds ratio = 2.01; adjusted odds ratio = 1.95; 95% confidence interval, 1.4-2.8; P < 0.001) and 120 to 60 minutes (crude odds ratio = 1.75; adjusted odds ratio = 1.74; 95% confidence interval, 1.0-2.9; P = 0.035) as compared with the reference interval of 59 to 30 minutes before incision.ConclusionsWhen cefuroxime is used as a prophylactic antibiotic, administration 59 to 30 minutes before incision is more effective than administration during the last half hour.

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