• Pediatric neuroscience · Oct 1986

    Comparative Study

    Haloperidol, fluphenazine and clonidine in Tourette syndrome: controversies in treatment.

    • H S Singer, K Gammon, and S Quaskey.
    • Pediatr Neurosci. 1986 Oct 16;12(2):71-4.

    AbstractThe value of haloperidol, fluphenazine and clonidine as therapeutic agents for Tourette's syndrome was retrospectively reviewed. Haloperidol improved tic symptoms in 50/60 patients, but side effects often nullified these benefits. Fluphenazine was an effective drug for tic suppression in 24/31 patients. Direct comparison of these drugs in 23 patients confirmed the efficacy of fluphenazine and showed it to produce fewer adverse effects than haloperidol. Clonidine was helpful in 47% and caused few side effects. These results support the use of clonidine for the treatment of tics and suggest that fluphenazine can be considered an alternative to other neuroleptic drugs.

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