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Clinics in chest medicine · Dec 2008
ReviewCorticosteroids and human recombinant activated protein C for septic shock.
- Gwenhaël Colin and Djillali Annane.
- Assistance Publique Hôpitaux de Paris, General Intensive Care Unit, Hôpital Raymond Poincaré (AP-HP), Université de Versailles SQY (UniverSud Paris), 104 Boulevard Raymond Poincaré, 92380 Garches, France. djillali.annane@rpc.aphp.fr
- Clin. Chest Med. 2008 Dec 1;29(4):705-12, x.
AbstractThis article summarizes the current knowledge on the benefit/risk profile from the use of low-dose corticosteroids and activated protein C in treating septic shock. Physicians should consider using low-dose corticosteroids and drotrecogin alpha activated in the treatment of patients who have vasopressor-dependent septic shock with persistent signs of hypoperfusion, organ dysfunction, or hypotension. The optimal timing for initiating these treatments is from 6 to 24 hours from onset of shock. When patients are receiving these drugs, physicians should systematically screen for superinfection and serious bleeding events.
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