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- I G Skipsey, J R Colvin, N Mackenzie, and G N Kenny.
- Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee.
- Anaesthesia. 1993 Mar 1;48(3):210-3.
AbstractThe ability of a target-controlled propofol infusion system to provide sedation for 40 patients undergoing surgery under regional blockade was assessed. Eighty-eight per cent of the total infusion time was at the desired sedation level with little oversedation. This was achieved with a median blood propofol concentration of 0.93 micrograms.ml-1. The pharmacokinetic algorithm performed as well when used for sedation as for total intravenous anaesthesia. The predicted and measured blood propofol concentrations showed a bias of -12% and a precision of 34%.
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