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Antimicrob. Agents Chemother. · Dec 1996
Effect of gentamicin dosing interval on efficacy of penicillin or ceftriaxone treatment of experimental endocarditis due to penicillin-susceptible, ceftriaxone-tolerant viridans group streptococci.
- C M Brandt, C B Warner, M S Rouse, J M Steckelberg, and W R Wilson.
- Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
- Antimicrob. Agents Chemother. 1996 Dec 1;40(12):2901-3.
AbstractThe efficacy of ceftriaxone or penicillin alone or combined with gentamicin at different dosing intervals was evaluated in experimental endocarditis due to a penicillin-susceptible, ceftriaxone-tolerant strain of Streptococcus sanguis I. The difference between monotherapy with ceftriaxone and procaine penicillin approached statistical significance (P = 0.052). Ceftriaxone combined with gentamicin administered as a single daily dose was less effective than was procaine penicillin combined with gentamicin administered in a single daily dose or in three divided doses.
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