• E Dogu, A Stöhr, R Zick-Bögemann, C Hegeler-Molkewehrum, H Hartmann, and H J Engel.
• Kardiologische Abteilung des Zentralkrankenhauses, Links der Weser, Senator-Wessling-Strasse 1, 28277 Bremen, Germany.
• Z Kardiol. 2004 May 1;93(5):403-6.

AbstractPlatypnea-orthodeoxia is a rare syndrome that is often associated with interatrial shunting through a patent foramen ovale (PFO) or atrial septal defect. We describe the case of a 69-year-old woman with progressive dyspnea and hypoxia when standing, which was relieved by assuming the recumbent position. After detection of a PFO by transesophageal echocardiography the diagnosis was confirmed by transthoracic echocardiography using saline contrast injection while lying supine and standing upright. This maneuver demonstrated a large right-to-left shunt through a patent foramen ovale while the patient was in a upright position and no significant shunt while being in a recumbent position. The patient showed a rapid improvement after closure of the PFO. This case demonstrates that platypnea-orthodeoxia caused by a patent foramen ovale can be easily demonstrated by the technique of contrast transthoracic echocardiography and a simple positioning maneuver.

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