• J Pediatr Ophthalmol Strabismus · Nov 2003

    Topical mydriatic and cycloplegic spray for Chinese children.

    • Chun-yu Wong, Dorothy S P Fan, Christopher B O Yu, and Dennis S C Lam.
    • Hospital Authority Ophthalmic Services, Hong Kong Eye Hospital, Kowloon, People's Republic of China.
    • J Pediatr Ophthalmol Strabismus. 2003 Nov 1;40(6):349-52.

    PurposeTo assess the efficacy and tolerance of mydriatic and cycloplegic spray versus drops for Chinese children.MethodsThe effects of the spray (cyclopentolate 0.25%, phenylephrine 0.625%, and tropicamide 0.5%) and the drops (cyclopentolate 1%, phenylephrine 0.5%, and tropicamide 0.5%) were evaluated in 29 children (58 eyes) in two separate sessions. There was a 1-week period between the applications of the spray and the drops. Dilated pupil size and refraction after cycloplegia were the primary outcome variables used to assess the efficacy. A subjective discomfort score was used to assess acceptance of the spray and the drops.ResultsThe mean age of the study population was 4.33 +/- 1.39 years (range, 3 to 8 years). The mean pupil size was 6.9 mm for the spray and 6.6 mm for the drops. The spray appeared to be slightly more effective than the drops, with a mean difference of 0.3 mm that was statistically significant (P = .001, two-tailed t test). No statistically significant difference in cycloplegic response was found between the spray and the drops (P = .535, two-tailed t test). Administration of the spray caused less discomfort than did administration of the drops (P < .001, Wilcoxon signed-rank test).ConclusionsThe spray system appears to be clinically equivalent to the drops for achieving effective pupil dilation and cycloplegia, even in a population with dark irides such as ours. Tolerability and acceptance improved because the spray was applied to the closed eyelids.

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