• Boubaker Charra, Abdelhamid Hachimi, Abdellatif Benslama, and Said Motaouakkil.
• Medical Intensive Care Unit, Ibn Rochd University Hospital, Casablanca, Morocco.
• Pan Afr Med J. 2014 Jan 1;18:35.

IntroductionThe aim of the study is to compare efficacy of IvIg versus PE in treatment of mechanically ventilation adults with GBS in intensive care unit.MethodsIt is a prospective, non randomized study, realized in a medical ICU from 2006 to 2010. We included all patients with GBS who required mechanical ventilation (MV). We defined two groups: group 1 (group treated by IvIg: 0.4 g/kg/day for 5 days) and group 2 (group treated by PE: 4 PE during 10-14 days). We collected demographic characteristics, clinical and therapeutic aspects and outcome.Statistical Analysis UsedThe quantitative variables are expressed on mean ± standard derivation and compared by Student test. The statistic analysis has been based on SPSS for windows. P<0.05 is considered as significant.ResultsForty-one patients (21 in group 1 and 20 in group 2) were enrolled. The mean age was 37.4±9.2 years, with a masculine predominance (75.4%). Electromyogram in all patients found acute inflammatory demyelinating polyradiculoneuropathy in 80.5% of patients. The mean length of hospitalization was 45.3±9.2 days. The length of hospitalization of the IvIg group is less long than PE group (p=0.03). The weaning of the MV was more precocious in IvIg group than PE group (p=0.01). Also, the beginning of motility recuperation was precocious at IvIg group than PE group (p=0.04).ConclusionOur work reveals a meaningful difference for the MV weaning and precocious recovery in IvIg group compared to PE group.

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