• Debaroti M Borschel, Carol E Chenoweth, Samuel R Kaufman, Kristi Vander Hyde, Kristen A VanDerElzen, Trivellore E Raghunathan, Curtis D Collins, and Sanjay Saint.
• Department of Internal Medicine, University of Michigan, Ann Arbor, 48109-0376, USA. dborsche@umich.edu
• Am J Infect Control. 2006 Aug 1;34(6):388-93.

BackgroundCatheter-related bloodstream infections are common, costly, and morbid. Randomized controlled trials indicate that antiseptic-coated central venous catheters reduce infection rates.ObjectiveTo assess the clinical and economic effectiveness of antiseptic-coated catheters for critically ill patients in a real-world setting.MethodsCentral venous catheters coated with chlorhexidine/silver-sulfadiazene were introduced in all patients requiring central venous access in adult intensive care units at the University of Michigan Health System, a large, tertiary care teaching hospital. A pretest-posttest cohort design measured the primary outcome of catheter-related bloodstream infection rate, comparing the 2 years prior to the intervention with the 2 years following the intervention. We also evaluated cost-effectiveness and changes in vancomycin use.ResultsThe intervention was associated with a 4% per month relative reduction in the incidence of catheter-related bloodstream infection, after controlling for the effects of time. Overall, a 35% relative risk reduction (P < .0003) in the catheter-related bloodstream infection rate occurred in the posttest phase. The use of antiseptic-coated catheters reduced costs more than $100,000 annually. Vancomycin use was less in units in which antiseptic catheters were used compared with wards in which these catheters were not used.ConclusionAntiseptic-coated catheters appear to be clinically effective and economically efficient in a real-world setting.

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